Ecarin is a snake venom (Echis carinatus) that directly activates prothrombin to meizothrombin This action is not dependent on phospholipid membranes and . Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting . In this research, the effects of Echis carinatus crude venom and its fractions on mice were analyzed. Moreover, the results of coagulation tests.

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High populations in some areas may be due to this generalist diet. Some of Ec venom compounds may also be purified and used as procoagulant medicines. Inhibition of procoagulant activity.

Their results corroborate ours concerning blood coagulation and anticoagulation carinatud [ 26 ]. Since blood exhis consist of platelets and fibrin, treatment strategies have been developed based on coagulation, fibrinolysis and platelet functions.

The fractions with proguaolant activity were pooled, lyophilized and dialyzed against 50 mM Tris-HCl, pH 8. Ec crude venom was primarily isolated using gel chromatography Sephadex G column which initially gained equilibrium using 20 mM ammonium acetate buffer pH 6.

Other Shock secondary to fluid shifts due to local tissue injury is likely in severe cases. Midbody schis are rows of dorsal scales that are keeled scales with apical pits; on the flanks, these have serrated keels.


Purification, cloning and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin from Bothrops jararaca venom. In contrast to our results reported in the previous work [ 17 ], the oral route when compared to a general acute toxicity index showed normal with no extraordinary symptoms as well as no acute toxicity. Times for prothrombin, partial thromboplastin and fibrinogen were recorded. Snakebite affects around 2. Fixed dose of E.

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Broken down fibrinogen peptides are somehow similar to fibrin without transverse links which are quickly removed from the blood circulation. Helene H, Cassian B. Purification and isolation of prothrombin activator Purification of the prothrombin activator was performed in three steps. Group 2 was divided into 6 equal subgroups G2.

Siigur E, Siigur J. Snake Species of the World: The basis for reassurance is the fact that many venomous bites do not result in envenoming, the relatively slow progression to severe envenoming hours following elapid bites, carintus following viper bites and the effectiveness of modern medical treatment.

Echis carinatus is one of the venomous snakes in Iran. Life threatening intracerebral haemorrhage following saw-scaled viper Echis carinatus envenoming-authenticated case report from Sri Lanka.

Rosing J, Tans G. Our observation showed that the molecular weight of F 1 Carinatuz 4 is similar to prothrombin activator enzymes which have been already reported Besides FXa, these enzymes act independently, eliminating the use of any cofactors, including FV, on carboxilated or nonocarboxilated prothrombin.


There are interocular scales across the top of the head and circumorbital scales. Trustees of the British Museum Natural History.

Accessed 21 September Statistical results suggest that H 0 is rejected by both subfractions F 1 A and F 1 B and, hypothetically, H 1 is accepted by both.

As soon as the snae signs of clotting were observed, time was recorded and the fibrinogen level determined [ 1213 ]. The result was significant, and the extract czrinatus found to inhibit dose dependently the venom-induced haemorrhagic oedema. A Taxonomic and Geographic Reference, Volume 1.

Abstract Background The venom of the family Viperidae, including the saw-scaled viper, is rich in serine proteinases and metalloproteinases, which affect the nervous system, complementary system, blood coagulation, platelet aggregation and blood pressure.

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Renal Damage Recognised complication, usually secondary to coagulopathy. Comparison of the prothrombin time before and after F1A and F1B administrations showed that time for blood coagulation after injection is shorter than that of normal blood coagulation and also reduced coagulation time after Ec crude venom injection. The subfractions were pooled and dialyzed like vwnom gel chromatography. All animals were observed over 24 hours.